Publications

Explore our growing list of publications to learn more about our scientific contributions and areas of expertise.

2025

Brunmeir, R., Ying, L., Yan, J. et al. EZH2 modulates mRNA splicing and exerts part of its oncogenic function through repression of splicing factors in CML. Leukemia (2025). https://doi.org/10.1038/s41375-024-02509-y

2024

Xiong S, Zhou J, Tan TK, Chung TH, Tan TZ, Toh SH, Tang NXN, Jia Y, See YX, Fullwood MJ, Sanda T, Chng WJ. Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma. Nat Commun. 2024 Aug 9;15(1):6810. PMID: 39122682;

Lao ZT, Ding LW, Sun QY, Li J, Yan BJ, Ng AYJ, Capinpin SM, Wang R, Li Y, Chng WJ, Koeffler HP Koh WP, Yuan JM, Yang H, Goh YT, Grigoropoulos N (2024) A pre-leukemic DNA methylation state in healthy individuals associated with risk of myeloid malignancy. Clin Cancer Res. Online ahead of print.

Tai YT, Lin WC, Ye J, Ting-Hsian Chen D, Chen KC, Yi-Te Wang D, Tan TZ, Wei LH, Yun-Ju Huang R. Spatial profiling of ovarian clear cell carcinoma reveals immune-hot features. Mod Pathol. 2024 Oct 10:100630. PMID: 39395637.

Lim KK, Lam UTF, Li Y, Zeng YB, Yang H, Chen ES. Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A. Nucleic Acids Res. 2024 May 8;52(8):4198-4214. doi: 10.1093/nar/gkae084. PMID: 38442274; PMCID: PMC11077061.

Kong LR, Gupta K, Wu AJ, Perera D, Ivanyi-Nagy R, Ahmed SM, Tan TZ, Tan SL, Fuddin A, Sundaramoorthy E, Goh GS, Wong RTX, Costa ASH, Oddy C, Wong H, Patro CPK, Kho YS, Huang XZ, Choo J, Shehata M, Lee SC, Goh BC, Frezza C, Pitt JJ, Venkitaraman AR. A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2. Cell. 2024 Apr 8:S0092-8674(24)00255-1. PMID: 38608703.

2023

Zhou J, Toh SH, Tan TK, Balan K, Lim JQ, Tan TZ, Xiong S, Jia Y, Ng SB, Peng Y, Jeyasekharan AD, Fan S, Lim ST, Ong CJ, Ong CK, Sanda T, Chng WJ. Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma. Mol Cancer. 2023 Apr 10;22(1):69. doi: 10.1186/s12943-023-01767-1. PMID: 37032358.

Krishnan V, Schmidt F, Nawaz Z, Venkatesh PN, Lee KL, Ren X, Chan ZE, Yu M, Makheja M, Rayan NA, Lim MGL, Cheung AMS, Bari S, Chng WJ, Than H, Ouyang J, Rackham O, Tan TZ, Hwang WYK, Chuah C, Prabhakar S, Ong ST. A Single-cell Atlas Identifies Pretreatment Features of Primary Imatinib Resistance in Chronic Myeloid Leukemia. Blood. 2023 Mar 1:blood.2022017295. PMID: 36857629.

Tan VJ, Liu T, Arifin Z, Pak B, Tan ASC, Wong S, Khor CC, Yang H, Lee CG, Huang Z, Choolani MA, Chong SS (2023). Third-Generation Single-Molecule Sequencing for Preimplantation Genetic Testing of Aneuploidy and Segmental Imbalances. Clin Chem 69: 881-889.

Ran XB, Ding LW, Sun QY, Yang H, Said JW, Lao Z, Madan V, ... (2023) Targeting RNA exonuclease XRN1 potentiates efficacy of cancer immunotherapy. Cancer Res. 83:922-938.

Yeo XH, Sundararajan V, Wu Z, Phua ZJC, Ho YY, Peh KLE, Chiu YC, Tan TZ, Kappei D, Ho YS, Tan DSP, Tam WL, Huang RY. The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer. Commun Biol. 2023 Jun 22;6(1):660. doi: 10.1038/s42003-023-05045-0. PMID: 37349576; PMCID: PMC10287694.

2022

Pang QY, Tan TZ, Sundararajan V, Chiu YC, Chee EYW, Chung VY, Choolani MA, Huang RY. 3D genome organization in the epithelial-mesenchymal transition spectrum. Genome Biol. 2022 May 30;23(1):121. PMID: 35637517